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And while the Liberal Democrats' national share of the vote has been severely hit under the coalition, the party is still clinging to the hope that it may hold on in its established strongholds.
The days of the digital versatile disc may well be coming to an end, at least in its established form as a factory pressed, attractively packaged object of mass consumption.
Last year Baxter International scored record sales of $7.7 billion, mostly in its established medical-equipment businesses focusing on drug-delivery systems, blood collection and kidney dialysis.
Going forward it has its eyes set on more growth in its established markets, but also building out in to new ones such as Brazil.
Although BlackBerry is a must-have accessory for the growing business class in the developing economies of the world and RIM is adding customers there at a healthy clip, the company faces a problem in its established markets.
A slowdown in its established markets, volatile prices for raw material and ever-fiercer competition from Asia have posed serious problems for the European manufacturers who dominate in Milan.
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Our findings indicate that ATGL functions as REH in HSCs in addition to its established role in TG catabolism.
"The agency's success in meeting its established performance goals may be overstated," the report said.
TFIIS, in addition to its established role in promoting transcript cleavage, is found to relieve arrest by a second, cleavage-independent mechanism.
These data indicate that, in addition to its established role in extending telomeres, TERT can promote proliferation of resting stem cells through a non-canonical pathway.
In addition to its established role in muscle development, little is known about the function of LHX6, especially in cancer.
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CEO of Professional Science Editing for Scientists @ prosciediting.com