Sentence examples for in its activation from inspiring English sources

This IFN-inducible kinase has two distinct activities: autophosphorylation, resulting in its activation, and phosphorylation and inactivation of eIF2α.

Human Mps1 auto-activates by phosphorylating T676 in its activation loop.

ROS oxidize cysteine residues of the Trx protein causing it to dissociate from ASK1 resulting in its activation through autophosphorylation.

The crystal structure of Haspin suggests that the activation loop in the kinase domain naturally adopts an active conformation and, unlike other kinases, it does not contain any phosphorylatable residues in its activation loop (Villa et al. 2009).

AMPK activity is absolutely dependent upon phosphorylation of AMPKalphaThr-172 in its activation loop by one or more AMPK kinases (AMPKKs).

It has also been demonstrated that Hippo is phosphorylated in its activation loop by Tao-1, another member of the sterile 20-like kinase family.

pSyk (Y525/526) and pERK (Y202/204) represent activated enzymes while de-phosphorylation of Y527 of Src results in its activation.

This is, to our knowledge, the first example of a Ser/Thr kinase whose activity is controlled by the phosphorylation state of adjacent residues in its activation loop.

It is known that phosphorylation of Y397 of FAK results in its activation.

Wakimoto, H. et al. The complement response against an oncolytic virus is species-specific in its activation pathways.

The c-Myb protein plays a key role in normal hematopoiesis, and truncation results in its activation to a transforming protein.