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Because it is unlikely that a potent repressor such as Su z 2 directly interferes with repression, we suppose that its role in interference with auto-repression is indirect.
In addition, patients believed larger improvements in interference with daily activities were warranted before treatment was considered successful (vs reduction in pain and fatigue).
Kloss et al. reported a nonsynonymous damaging variant in CSNK2B (c.473 A > G resulting in p. Tyr158Cys) among high myopia families, resulting in interference with the Wnt signaling pathway93.
TCM provided significantly greater short-term (8-week) relief than SC (CFP reduction difference, −.60 [standard deviation of the estimate.26], P =.020) and greater reduction in interference with social activities (−.81 [standard deviation of the estimate.33], P =.016).
Individual comparisons (adjusted for multiple comparisons) indicated that the reduction in interference with daily activities needed to be considered successful was significantly greater than that for pain reduction (P=.002) or fatigue reduction (P=.002).
Patients considered mean reductions in pain of 3.44±1.85 points (56% reduction), in fatigue of 3.35±2.10 (57% reduction), in emotional distress of 3.64±2.90 (65% reduction), and in interference with daily activities 4.3±2.6 points (68% reduction) to be successful treatment outcomes.
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The intervention resulted in significant decreases in pain interference with daily activities and increases in participants' self-reported ability to cope with pain.
In contrast, interference with SMAD4 expression in EC does not result in EC clusters, but in defective recruitment of pericytes (25).
Non-DPN Celliant™ subjects reported 34% more reduction in interference compared with controls (p = 0.760).
In summary, interference with chemokine-GAG interactions in donor aortic allograft transplants significantly inhibits accelerated transplant plaque growth, a reduction equipotent to blockade of chemokine-CCR2 interactions.
In zebrafish, interference with F11r function causes defects in migration at later stages of development [ 48].
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