In the three studies providing information on intended prescription of high doses [ 29, 34, 39], there was no clear tendency for excessive doses to be more frequently prescribed than insufficient doses.
Despite the limitations of this study (for example, small population size with imbalances in baseline characteristics, lower protein C levels than in PROWESS and potentially insufficient dosing), DrotAA cannot be recommended for use in children with severe sepsis.
The growth energy of the untreated (controlled) tumor was 1.0091 J, while the decay energy of the insufficient dose from In-111 = 0.816 J only.
Waisel wrote to the court: "In light of the insufficient dose of midazolam, it is substantially likely that McGuire [is at] substantial, palpable, objectively intolerable risk of experiencing the agony and horrifying sensation of unrelenting air hunger.
Physicians were, therefore, hesitant to use antivenom, and fear of dangerous side effects led to delays in administration and to insufficient dosing.
In order to avoid insufficient dose coverage at the peripheral PTV after using the FSCBs, the block auxiliary structure was sufficient to cover region expanding 1.5 cm from the PTV margin in 3 dimensions.
This situation could result in tumor recurrence (due to an insufficient dose) or severe side effects in normal tissues (due to an excessive dose).
Even in the context of a clinical trial, severely obese patients were almost three times more likely to receive suboptimal doses from the start, and this insufficient dose was maintained in subsequent cycles in more than 90% of cases.
Erythropoietin may have failed in clinical trials due to insufficient dose.
The increase in transaminases is usually linked to an insufficient dose of deferasirox and an increase in the hepatic iron overload.
