Exact(1)
Although the details vary with the different patients, in principle the data illustrate that the imatinib-resistant mutant clone that predominates in initial recurrence of disease declines to undetectable levels when de-selected but can reappear when the therapy, for one reason or another, is changed again.
Similar(59)
There were no significant differences in the initial recurrence pattern between mGPS-0, -1, and -2 (P = 0.126).
Seeding metastases in the laparotomy scar occurred as initial recurrence in 7 patients, including 3 patients (3.4 %) in the PTBD group and 4 patients (2.7 %) in the EBD-only group (P = 0.71).
Seeding metastases occurred as initial recurrence in 3 (3.4 %) of 87 patients in the PTBD group (95 % CI 0 7.3), and in 4 (2.7 %) of 147 patients in the EBD-only group (95 % CI 0 5.3; P = 0.71).
No patient had an initial recurrence in percutaneous catheter tracts.
In addition to the initial recurrence date, confirmatory dates for all positive diagnostic measures within a predetermined 60 days clinical time frame were documented for the purpose of comparative evaluation.
Moreover, PTBD was not associated with an increase in seeding metastases developing as initial recurrence that would potentially affect survival.
The present study found no effect of PTBD on survival compared to patients with EBD and no increase in seeding metastases that developed as initial recurrence.
The present study found no effect of PTBD on survival compared to patients who underwent preoperative EBD and no increase in seeding metastases that develop as initial recurrence.
If a patient's symptoms were noted during physical exam or history, but the CA-125, vaginal cytology and imaging results were negative, the initial recurrence was classified in accordance with the physical exam.
If the patient had negative imaging, physical and vaginal cytology findings, but the CA-125 was indicative of disease progression, the initial recurrence was classified in accordance with the CA-125.
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