TET-inducible histone expression combined with ChIP-Seq typically result in initial increases, followed by decreases in read density over many genomic regions due to read coverage limitations [ 13, 18, 19].
In vivo, reduction in PHB levels resulted in an initial increase in tumour size, regardless of androgen treatment.
This increase coincided with maximum peroxidase activity in resistant roots, and may be related to the decline seen in the initial increase in H2O2 at these times points in inoculated resistant plants.
Fluid restriction was initiated in an effort to resolve the hyponatremia; this resulted in an initial increase in serum [Na+], however, the concentration remained below the normal range of 135 mmol/L after 15 days.
Occlusion at 35 degrees C, i.e. to maintain tumour temperature during occlusion, resulted in an initial increase in LACTe, which mirrored a rapid reduction in pHe.
In the ras-transformed mouse fibroblasts, ras expression resulted in an initial increase in p21cip1 (a Cdk2 inhibitor) levels and inhibition of Cdk2 activity, followed by a decrease in p21cip1 and activation of Cdk2, producing increased H1b phosphorylation [ 26].
Depletion of IL-17A in mice during pulmonary infection with C. neoformans strain H99γ resulted in an initial increase in pulmonary fungal burden, but had no effect on cryptococcal burden at later time points.
The relationship between oxygen concentrations and heterogeneity of oxidative metabolism resulted in an initial increase in metabolic heterogeneity over time followed by a decrease when anoxic conditions dominated.
The reduction in the number of stems from 813 to 400 stems ha−1 following the first thinning resulted in an initial increase in understorey vegetation.
Exposure to 20 μM 6′-OH-BDE-49 results in an initial increase in 50% of the cells.
