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Analysis of LUC activity demonstrated that the co-transfection of EnS44:fLUC, α-Glb:fLUC, and ONAC024:fLUC with OsSMF1 resulted in induction of the expression of the luciferase reporter gene by 23.7-, 33-, and 51.3-fold, respectively, compared with co-transfection of HRGP:fLUC (Fig. 6).
31– 34 It has been shown that subjecting cultured macrophages to immunogenic stimuli results in induction of the expression of a specific group of lncRNAs, demonstrating that the expression of at least some lncRNAs is regulated.
Although the pentaacyl bisphosphate Lipid A 2 revealed no activity at all, the Ara4N-modified Lipid A 1 was efficient in induction of the expression of IL-8, though again at significantly higher doses than E. coli LPS.
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S1P associates with HDL exerting synergic function in induction of the COX-2 expression and prostaglandin I-2 release [ 10, 14, 15].
We demonstrate here that silencing of ADAR1 leads to decreased global editing levels of Alu sequences in hESCs and results in significant induction of the expression of genes related to development and differentiation.
In this regard, vGPCR has been implicated in the induction of the expression of VEGF, a key angiogenic factor highly upregulated in KS [17], [18].
Our analyses showed no changes in EcR transcriptional levels in CTCF mutant animals and only a delay in the induction of the expression of E75B and PTTH, each of which eventually showed transcript levels similar to controls (Fig. 1B).
Our results seem to support the involvement of H2O2 in the induction of the expression of the PAL genes in resistant tomato plant roots, although this effect was less apparent in susceptible plants.
Overall, these observations suggest that activation of the Cn/NFATc2 signaling pathway is involved in the induction of the expression of some signaling molecules that inhibit proliferation and induce terminal differentiation in keratinocytes.
The first consists in Myc induction of the expression of p19ARF which stabilizes p53 [41], [41], and the second in the promotion by Myc of the cytochrome C release from mitochondria in a p53-independent manner [42].
Consistent with the markedly increased hepatic bile acid levels at ZT2 (Figure 1A and B), the RF regimen resulted in modest induction of the expression of CAR and PXR target genes, including Cyp2B10, Cyp3A11, Cyp2C29 and GST-Pi (Figure 4A).
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