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In addition, maximal strength and power in individual limbs are strongly correlated with mobility in older adults [ 12].
Stratifying individual limb kinematics by OA scores in individual limbs may provide better insight into OA-dependent kinematic changes.
Joint swellings in individual limbs were scored as follows: 0, no joint swelling; 1, swelling of one finger joint; 2, mild swelling of a wrist or ankle; and 3, severe swelling of a wrist or ankle.
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Alterations in individual limb movements were restricted to off-axis (horizontal and vertical) trajectories.
To be clear, we agree that there are clearly differences in individual limb movements in pcd, as is shown in Figure 3.
Also in the subsection "A quantitative framework for locomotor coordination reveals fundamental features of mouse gait ataxia" we emphasize that "observed differences in traditional gait parameters were a secondary consequence of differences in body size and walking speed"; there are real differences in individual limb movements in pcd.
While traditional gait analyses in ataxic mutants have reported a variety of impairments in individual limb movements and interlimb coordination (Fortier et al., 1987; Wang et al., 2006; Vinueza Veloz et al., 2014), many of these findings are not specific to ataxia and could represent secondary consequences of changes in walking speed (Batka et al., 2014).
If the authors are the first to show that mice with cerebellar deficits have a specific impairment in locomotor coordination but not in movement of individual limbs, this is a big deal.
This is an important point, but please note that the last line of the legend for Figure 3 states, "For E-H controls are size-matched control see Figure 2 figure supplement 1", and that at the end of the subsection "Changes in gait parameters for individual limbs are predicted by changes in walking speed and body size" we state: " pcd animals are compared with size-matched controls from here on".
Other papers have shown deficits in both stride parameters of individual limbs and interlimb coordination in ataxic mutants (e.g. Vinueza-Veloz 2014).
For example, Figure 3B-E shows that there is no difference in the individual limb kinematics of pcd mice and sized-matched controls.
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