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Zymogenic cells synthesize and store zymogens in inactive form.
VIIa also circulates in inactive form, in complex with antithrombin (VIIaAT) formed when VIIa is bound to tissue factor (TF).
Bax-α exists in inactive form and several conformational changes are required during apoptosis to activate it.
Chymotrypsin, a digestive protease, is produced in inactive form as chymotrypsinogen in the pancreas and transported in this form to the stomach where it is activated.
We observed that metabolic stressed-induced Snail protein aggregates are colocalized with mitochondria, possibly in inactive form in which its transcriptional activity was impaired [55].
A large number of circulating proteins, usually in inactive form, are involved in the haemostatic cascade.
TGF-β is secreted in inactive form which is then activated following proteolysis [ 21].
Urokinase-type PA (uPA), which is secreted in inactive form (pro-uPA), plays a key role in ECM degradation.
As β starts to become comparable to 1, we immediately find that the assumption that most of the enzymes are present in inactive form starts to break down.
The bone could be a "fertile" soil because it is a reservoir of growth factors; however, these factors are not immediately available because they are stored in the mineralized matrix or present in inactive form.
The treatment of 10 m m D-ribose for 24 h resulted in a significant increase in active form of CaMKII (p-Thr286), yet simultaneously in a decrease in inactive form of CaMKII (p-Thr305) phosphorylation (Fig. 4e).
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