Sentence examples for in improved whole from inspiring English sources

As summarized in Table 2, these initial investigations reveal that even partial GHD has a dramatic impact on metabolic function resulting in improved whole body insulin sensitivity independent of diet.

In recent studies, FTY720 has been shown to inhibit the development of obesity in high fat fed mice, by modulation of adipogenesis and lipolysis [ 105], and to attenuate the accumulation of ceramide in muscles, associated with a high fat diet, resulting in improved whole body glucose homeostasis [ 106] and amelioration of prediabetic type 2 disposition.

Furthermore, genetic ablation of GSK-3α results in improved whole-body glucose tolerance that is accompanied with enhanced hepatic insulin signaling and elevated glycogen accumulation [11].

Others 33 have also observed a reduced oxidative capacity in mice with improved whole body glucose utilization and insulin-stimulated glucose uptake.

However, the role of the intestine in the improved whole-body metabolic phenotype has not yet been analysed in detail.

Therefore, the goal of this study is to define an improved whole genome sequence (WGS) for this organism using in-depth molecular profiling by RNA-seq transcriptomics and tandem mass spectrometry-based proteomics.

Improved whole body glucose disposal following training has been associated with an increase in insulin stimulated glycogen synthesis [ 38].

Notably, decreased steatosis in obese Opn−/− mice was paralleled by improved whole-body insulin sensitivity, which was mainly due to reduction in hepatic insulin resistance and glucose production as revealed by euglycaemic hyperinsulinaemic clamp studies (Fig.  2).

A significantly increased glucose infusion rate in HFD-fed FasΔmye compared to FasF/F mice was noted, consistent with improved whole-body insulin sensitivity (see Fig  3A and supplementary Fig 10A C for detailed time courses).

Thus, the improved whole-body insulin sensitivity and reduced hepatic and visceral lipid content is attributed at least in part to the hyperplasic increase in subcutaneous adipose tissue seen in patients or animal models treated with TDZ [104 106].

In the present paper we show that mice lacking BACE1 are lean, resistant to diet-induced obesity, and display increased peripheral tissue insulin sensitivity with improved whole-body glucose disposal.