Letocetum lost all importance with the development of nearby Lichfield in the 7th century as the seat of a Bishop.
Its commercial importance declined with the development by the Iranian government in the 1960s and '70s of Khorramshahr as the principal port for the Persian Gulf.
Finally, it is more prevalent in adolescence, a phase of life with great importance in the development of self-confidence and social abilities.
Theoretical (mathematical) models have grown in importance during the past decades, in combination with the development of computational resources.
Each scenario is driven by certain key factors with primary importance in the development of the correspondent pathway.
Human and rat normal tissues and tumours have been studied for the presence of toxic substances, possibly of importance in the development of cachexia in patients with cancer and other chronic diseases.
A patient-centered context is of central importance in the development of effective communication with patients.
Animal models reproducing infection with RVF virus are of upmost importance in the development of these disease control tools.
The identification of analogues with reduced hepatotoxic potential is, therefore, of particular importance in the development of novel therapeutics.
