In 3D human engineered cardiac tissues (hECTs), a blunted lusitropic response to β-adrenergic stimulation was observed with R9C PLN.
Biomimetics [1] reflects the features and capabilities of the biological evolution [2] of a system that could be efficiently replicated or mimicked in a human engineered system to the design of new technologies and the improvement of conventional ones.
This is, for instance, the case of the monitoring of chimeric luciferase/fluorescent protein expression by human engineered UCBMSCs in a mouse model of angiogenesis (Matrigel Plug Assay) [ 60].
To ascertain the physiological effects of p53 point mutation, the structural mutant p53R172H and the contact mutant p53R270H (codons 175 and 273 in humans) were engineered into the endogenous p53 locus in mice.
In humans, an engineered p75 TNFRII dimer, etanercept, suppressed the gene expression levels of Th17-related cytokines including IL-6 and IL-23 in cutaneous lesions of psoriasis [ 26].
Identification of statistical patterns from observed time series of spatially distributed sensor data is critical for performance monitoring and decision making in human-engineered complex systems, such as electric power generation, petrochemical, and networked transportation.
Hence, there may be no more reason to fear that our seeming perceptions of mind in others are undermined by such examples than to fear that our perception of objects in space is undermined by the existence of photography — in both cases, human engineers can be characterized as having figured out ways of creating perceptual illusions.
The allergic response in human beings is engineered by CD4+ T lymphocytes, which secrete TH2 cytokines in response to activation by allergen-derived peptides.
Given the prevalence of muscle diseases in human populations, an engineered tissue model of human skeletal muscle could provide a biologically accurate platform to study basic muscle physiology, disease progression, and drug efficacy and/or toxicity.
Here we demonstrate simultaneous two-photon fluorescence excitation of RFP, YFP, and CFP in human melanoma cells engineered to express a "rainbow" pallet of colors, using a novel fiber-based source offering energetic, three-color femtosecond pulses.
