Nevertheless, the possibility remains that the slight variation in expression between our knock-in human construct and the mouse gene could be attributable to influence from the Hprt locus.
In human constructs, the activity was largely restricted to the first 700 bp and decreased in larger constructs.
One possible reason is that there are more TFBS in human constructs to activate gene expression or fewer inhibitors to repress gene expression.
It is a "willed artifact, a human construct in which many conscious and unconscious factors played their part".
The law, in the final analysis, is a human construct whose application bears significant consequences on the experiences and lives it seeks to regulate.
Self-efficacy has been viewed as a key construct in human behavior and was identified as another essential component in our measure of self-management [ 13, 14].
Gorillas, orangutans, chimps and bonobos create nesting platforms in the trees, whereas modern humans construct beds to lie on.
I am interested, however, in moralities and how we humans construct them.
To address this knowledge gap, we studied how local strain and construct buckling in human TE constructs changes over culture times and GAG content.
These findings provide an opportunity to both better understand the mechanism of aberrant DNA methylation in human cancer and construct better GEMMs for therapy development.
Furthermore, the protective effects of CNP were enhanced with stimulation by mechanical loading in human chondrocyte/agarose constructs cultured with IL-1β.
