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This causes an unbalanced communication, overloading the receiver, which results in higher response times.
Although more intensive chemotherapy regimens often result in higher response rates in pilot trials, they do not offer significant gains in effectiveness or survival.
Combination chemotherapy results in higher response rates, however, superiority against single agent chemotherapy in terms of survival has not been established yet.
Pyridostigmine bromide delayed response acquisition in male and female rats, and resulted in higher response rates on the inactive lever in female rats than in male rats.
It has been proposed that co-transplantation of autologous megakaryocytes together with hematopoietic stem cells could result in higher response and survival rates for patients afflicted by the severe thrombocytopenia often associated with high dose chemotherapy and radiation therapy [39].
In patients with HCV infection, improvements in combination therapy have resulted in higher response rates.
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Whole-brain radiation therapy (WBRT) results in high response rates but rapid relapse, and this treatment is associated with delayed neurotoxicity in patients with PCNSL.
Treatment of EGFR-mutant non-small cell lung cancer patients with the tyrosine kinase inhibitors erlotinib or gefitinib results in high response rates and prolonged progression-free survival.
Regimens that have combined bortezomib with corticosteroids, alkylating agents, and immunomodulation drugs have resulted in high response rates [ 9].
In the POCHER trial, we showed that intensive chemotherapy with chrono-IFLO plus cetuximab resulted in high response rates, rapid tumour shrinkage and a resection rate of 60%.
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma.
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