Behavioral studies have documented a relative advantage in some aspects of visuospatial cognition in autism although it is not consistently found in higher functioning individuals with autism.
Although PPI is generally thought to be disrupted in higher functioning individuals with autism spectrum [80], [81], others have found limited evidence for sensorimotor gating abnormalities in a broader sample of ages and abilities [82].
In higher functioning older adults, FRT may not provide enough challenge in postural control system.
Nevertheless, scientists need to understand how the genes, whose expression was measured, are involved in higher functions of biological systems.
This may suggest that all FIM items are relevant in higher functioning groups (community residents) but not in lower functioning groups (patients in inpatient rehabilitation).
The Extended Mental State Exam EMSEE) [ 25] extends the widely used Mini Mental State Exam (MMSE) [ 35], a test known for its limitations [ 36, 37], in particular in higher functioning individuals [ 25].
The Screen for Cognitive Impairment for Psychiatry (SCIP) [ 18] was developed to offer a brief tool for the quantification of cognitive deficits in higher functioning psychiatric patients.
The SCQ might be less suitable for detecting subtle problems in higher functioning and/or younger children in general populations than for determining severe problems in lower functioning and/or older children in high-risk populations [ 3, 9, 13, 16].
For instance, one study recently reported that an increase in the diagnosis of ASD between 1983 and 1996 appeared to be due to greater recognition of ASD in higher functioning children initially presenting with attention deficit hyperactivity disorder (ADHD) [ 28].
In contrast to the interacting gene pairs, the median genomic distances are relatively close for non-interacting gene pairs in different bins, and gene pairs in high function similarity bins do not always have minimum median genomic distances.
