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FRS2 Is an Oncogene in High Grade Ovarian Cancer.
Ahmed, A. A. et al. Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary.
The extent of resection in high grade glioma is increasingly been shown to positively effect survival.
Effects were only evident in high grade tumors.
These findings point to a tumor suppressor role for miR-34c in high grade serous carcinomas.
P2X3 expression decreased in high grade carcinoma.
NF1 mutations are also common in high grade glioma in the general population.
Moreover, BMP4 was downregulated in high grade glioma when compared with low grade glioma.
Interestingly, LSD1 was significantly overexpressed in high grade DCIS versus low grade DCIS.
The mesenchymal marker Vimentin was expressed at higher levels in high grade tumors (p = 0.012).
However, KRAS was significantly amplified in serous tumors where mutations are rare in high grade tumors.
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