Exact(2)
Surprisingly not all of the translated uORFs contain initiation codons in good context.
The complex formed scans linearly along the 5′ untranslated region (UTR) until an initiation codon in good context is encountered, at which point further elements of translational machinery are recruited and protein synthesis starts.
Similar(58)
7) Could you include analysis of mRNAs either for the context around the AUG in the uORF or whether non-AUG codons might be used (if in a good context)?
We therefore considered this to be a good context in which to investigate the role of the core pathway in cell intercalation.
For there is only one good context in which to be dammed - when building a small island because you are a beaver.
Unlike the start codon of the main ORF, which in good initiation context is typically identified by the consensus Kozak sequence [ 21], many of the uAUGs are in sub-optimal context for translation [ 16].
Is the UUG in good sequence context or could this also be contributing to its initiation?
The continuation of such arguments underlines the need for more fossils to establish the range of physical variation of H. erectus and also for more discoveries in good archaeological contexts to permit more precise dating.
There are perfectly good contexts in which everything he says is true.
However, none of them are in a good sequence context in comparison with the optimal Kozak sequence, suggesting that they are unlikely to function as translation-initiating codons.
So, I think those kinds of stories are good in the right context, so to speak.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com