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Similar analyses were conducted for functional sequelae, where outcomes in logistic models represented worsening in global function score.
All three groups improved in global function, quality of life, depression, and self-reported memory abilities without significant group differences.
Our findings indicate that the reduction in global function is partly mediated by elevated mood.
A reduction in walking speed and an increase in double-support time indicated marked changes in global function (Table 2).
A statistically significant improvement in global function of patients treated by AChE inhibitors was previously reported in some studies [ 28- 30] but not in others [ 31].
Treatment difference in global function as measured by the CIBIC-plus scale numerically favored donepezil 23 mg/day but was not statistically significant.
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Also, children who showed greater consolidation of learning and memory strategies during treatment achieved greater improvement in global functioning at post-treatment.
In the majority of studies of OSA patients treated with CPAP, attention/vigilance improved, but changes in global functioning, executive functioning, and memory improved in about half of the studies.
In previous Korean studies, patients in the ACT program improved in global functioning [ 24, 25].
NPS are associated with decline in global functioning, increased use of medications and frequent hospitalization [ 6].
Secondary outcome measures were: improvement in global functioning and recurrence of depressive symptoms at the 12-months follow up visit.
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