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In this work we adopt a general multi-criteria framework and we propose the use of advanced numerical dynamic optimization techniques to study/predict enzyme activation in general pathways.
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Curated and systematic versions of these networks can be accessed in general pathway databases, such as KEGG [ 28] or the MetaCyc/BioCyc databases [ 29].
28, 29 As to which recombination/repair pathways mediate VSG interactions, some interesting novelties exist in the trypanosome general pathways, but a formal link has yet to be made.
In this general pathway, p50∶p65 dimers are sequestered in the cytoplasm by IκB proteins.
The pathway analysis revealed that, in general, distinct pathways were highly enriched among genes associated with each of the metals.
There are two general pathways in the adaptive immune system that are related to the expressed and secreted cytokine profiles.
However, a Ser/Thr kinase is important in a general pathway for endocytosis of Tf that is not dependent on DAG (Fig. 5A).
Thus, GA and DL are core compounds in a general pathway that maintains mitochondrial potential.
In this general pathway, it is believed that SNAIL 2 is initially induced, leading to the activation of TCF4 and FOXC2.
Although in general most pathways were represented at each time of infection (e.g. pathways involving genes that activate pathogen pattern recognition receptors), their ranking in the list varied (Additional file 4: Table S1).
In general, are pathways of amino acid sequences in modern protein-based organisms more conserved than some other pathways that might be considered to be less essential to cell function?
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