In general, dose enhancement factor (DEF) related to radiosensitive effect ranges from 1.01 to 2.11 [8], depending on various items, such as the dosage of radiation, concentration, size, morphology, surface coating, and charging of radiosensitizer.
The effects were, in general, dose-dependent.
Various studies have used different doses and schedules of HD-MTX, but in general, dose ≥3 g/m delivered as an initial bolus followed by an infusion over 3 hours, administered every 10 to 21 days is recommended for favorable outcomes and adequate CSF concentrations [ 25, 29, 30].
This experiment shows that with exception of the 4p, compounds have selectivity for tumor cells as they are in general, dose-dependent for tumor cells, but not for normal cells.> -wrap-foot> These concentrations were determined based on cells treatment for 72 h.
Long-term observational studies [ 13, 14] and numerous systematic reviews and meta-analyses of controlled trials have shown significant risk factor reductions following various types of PA interventions in a general dose-response pattern [ 15, 16].
In general, low doses and short term usage is very safe while higher doses used long term use can cause some side effects.
However, in general, high doses should be reserved for patients with very high levels of iron loading who are not responding to doses <30 mg/kg per d.
In general, repeated doses will have progressively greater effect and, in addition to extending the duration of surgical anaesthesia, can prolong the sleeping/recovery time following anaesthesia.
In general, repeated doses of anaesthetic drug will increase the depth and duration of the anaesthesia state, which could potentially prolong the recovery time.
In general, the doses used in animal studies are higher as compared to the background levels that humans are exposed to.
