Our data extend these findings to show that under conditions of differentiation in the absence of LIF and addition of RA, loss of Pten and increased phosphorylation of Akt attenuate the repression of Nanog and Oct4 mRNA as previously reported, but only in the emerging ECC population and not in the general differentiated population.
In general well differentiated tumour cells showed stronger immunoreactivity than less-differentiated cells.
In general, poorly differentiated tumours show large differences in cellular shapes and sizes and loss of histological structures.
Tumors that underwent the epithelial to mesenchymal transition (EMT) are in general less differentiated and more invasive, aggressive, and chemoresistant.
In general, poorly differentiated, high-grade carcinomas represent aggressive cancers that have a different natural history and response to treatment compared with well-differentiated, low-grade NETs.
A recent study documented not only that species are in general highly differentiated and monophyletic when considering a population tree, but also that most species can be individualized as discrete clusters by taking into account individual multilocus genotypes [ 18].
Indications for fertility-sparing surgery include, in general, a well differentiated low-grade tumor in its early stages or with low malignant potential.
Higher grade tumors in general are less differentiated, more pleomorphic, and more mitotically active, and they exhibit a tendency for decreased ALCAM transcript numbers.
These patterns suggest that circumference measurements tend towards allometric models suggested by McMahon [ 95, 96], whereas length measurements follow a pattern that, in general, cannot be differentiated from isometry when compared to body mass.
In general, fibrosis can be differentiated from tumor by the degree and kinetics of contrast enhancement.
