In general, compound-specific extraction efficiency depends on the physicochemical characteristics of the solid phase extraction [SPE] sorbents, the analytes, and the solvents used for elution.
In general, compounds having similar feature values are grouped together in one cluster.
In general, compounds of all three series exhibit similar HCA2 binding and activation profile.
In general, compounds belonging to the thiazolylantipyrine series exhibited better biological activities than their thiadiazolyl structure variants.
In general compounds with bulkier side chains displayed increased selectivity for nNOS over eNOS and iNOS isoforms.
In general, compounds with meta-substituted phenyl provided better selectivity for A2BAdoR compared to that of para-substituted analogs.
Binding data show that, in general, compounds 2 34 bind to the AMPA receptor with good affinity and selectivity.
As further evidence, a comparison of the compounds that are outside the descriptor boundary with those that are within the descriptor range shows that in general compounds with similar chemical and pharmacological nature can be found in both groups.
In general, compounds 2c and 3c were found to be equipotent at all the three different doses selected and with respect to BL 11282, both the test compounds were found to be more potent, at all the time points.
In general, compounds with lipophilic [5+6] bicyclic ring systems, such as the 7-benzothiophenyl and 4-indanyl groups, at the 5-position were 2 3 times more active against both fungal species as compared to 41F5.
