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57 In phase I and II studies, the dose of 60 mg every 6 months seemed to be the more effective dose and was thus investigated in further phase III studies.
Thus, whereas BOC and TVR have great promise for improved SVR in special populations, many complex treatment issues remain to be evaluated in further phase 2 and 3 testing.
Considering the potential of the S-1-based combination regimen, the combination of S-1 and the new cytotoxic agent in the present study deserves comparison in further phase III trials.
This 72-h schedule was subsequently investigated in further Phase I and Phase II trials in patients with mantle cell lymphoma, renal cancer, melanoma, gastric cancer, non-small-cell lung cancer (NSCLC) and colorectal cancers (Bennett et al, 1999; Stadler et al, 2000; Schwartz et al, 2001; Shapiro et al, 2001; Lin et al, 2002; Thomas et al, 2002).
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A regular determination of SMA in further phases provides information about development of sludge.
The analysis of this information can provide elements for delineating a range of interventions to be tested in further phases.
Under financial uncertainty, CIS top managers have thus convinced themselves and the other participants that this issue could be addressed in further phases of the project.
To assess whether services in further phases of development have taken more steps towards realising integrated care, we calculated the number of implemented elements that were considered relevant.
The majority of the excised bands were already found in the sample taken at the end of the first experimental phase, with the exception of bands B1, B4, B7, B17, B18, and B21, which were retrieved in further phases.
It would be interesting to see if integrated care services in further phases of development do have better outcomes on processes, patient satisfaction, quality of life or disease-specific indicators and costs.
The addition of bevacizumab to adjuvant chemotherapy (docetaxel/carboplatin or docetaxel FEC) and trastuzumab will be studied in a further phase III trial (BETH) in patients with HER2-positive breast cancer.
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