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Therefore, our studies have significant biological implications in further deciphering the detailed mechanisms whereby Hox genes are regulated to control hematopoiesis and leukemogenesis as well as devising novel therapeutic interventions by targeting the menin pathway in humans.
As the first potent, selective, and cell-active inhibitor of BRD7/9, LP99 will serve as a valuable tool in further deciphering the biological roles of these important BRD-containing proteins and serve as a starting point in the discovery of a new class of epigenetic therapeutics.
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The extended will retain the advantage of tags in homologs searching and offer us easiness in developing SNP detecting tools, and further deciphering the genetic bases of economic traits and cloning their controlling genes.
Subcellular localisation of DEC1 and its expression in oesophageal SCC tissues provide important insight for further deciphering the molecular mechanism of DEC1 in oesophageal SCC development.
In this regard, the P56S-MSP domain represents a unique model for further deciphering the general principles which direct folding, stability and evolution of membrane proteins.
Although they were not discussed in details in this paper due to the fact of no much functional information is available for them, we believe that further deciphering their functions will provide new insights to the stress responses in cyanobacteria.
Further, deciphering molecular mobility as a function of membrane topology was enabled.
These observations form an important framework for further deciphering the biological functions of heparin.
In order to further decipher the role of Itk we have investigated changes in gene expression of CD3+ as well as CD4+ and CD8+ T-lymphocytes in normal and Itk-defective mice.
Beyond the informative but obviously limited translational research performed in humans, some relevant animal models, mainly based on experimental sepsis, are being developed in order to further decipher the cellular and molecular mechanisms of CINM and to allow the preclinical evaluation of new therapeutics [53].
Beyond the informative but obviously limited translational research performed in humans, some relevant animal models, mainly based on experimental sepsis, are being developed in order to further decipher the cellular and molecular mechanisms of CINM and to allow the preclinical evaluation of new therapeutics [ 53].
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