Sentence examples for in fragile sites from inspiring English sources

The presence of unique DNA sequences in fragile sites may result in chromosome fragile site expressions.

All other chromosomes do not show any significant incidence difference in fragile sites versus non-fragile regions (see Table S3).

More than half miRNA genes are located in cancer-associated genomic regions or in fragile sites [6].

Calin et al. found that over half of the human miRNAs are located in fragile sites and genomic regions involved in cancer [37].

Moreover, 317 of 715 miRNAs (44.3%) are located within genes which are translocated in cancer and 87 of them (27.4%) are also in fragile sites.

Due to the discrete nature of the data, we used Poisson models to test whether miRNAs and protein coding genes appear more frequently in fragile sites.

In one case with positive t(14 16)(q32;q23), we found interstitial deletion in fragile site FRA16D including WWOX.

Although we did not address this question directly, our data suggested that transcription does not play a role in fragile site expression.

Taken together, our results indicate that histone modification and, by extension, chromatin conformation likely play a role in fragile site induction.

ATR protein was found to bind to three regions of FRA3B under conditions of replication stress, and a deficiency of ATR results in a dramatic increase in fragile site breakage [ 45, 46].

To examine the potential role of chromatin modification in fragile site expression, we analyzed several epigenetic modifications associated with open versus condensed chromatin at six CFS and their flanking NCFS sequences.