Our successful generation of a Lerp knockout mutant in Drosophila has allowed us to test the role of this transmembrane protein in development and in lysosome formation and function in an intact organism.
These loci encode proteins with central roles in neurogenesis, largely in the formation and function of the centrioles, which in turn control the way in which neural progenitor cells divide [ 16- 18].
The newly identified Nde1 partners cohesin and SNF2h are both known to participate in heterochromatin formation and function in multiple tissues.
The manuscript by Jenkins et al. describes the role of the kinase activity of Zap70 in synapse formation and function in cytotoxic CD8+ T lymphocytes.
The improvement in germline formation and function in lin-54 ; mes-4 double mutants likely reflects the restoration of gene expression patterns and levels closer to those appropriate for germ cells.
However, we note that MEFs have been used by other groups to study the roles of VHL, PDGFRαα, KIF3A and other proteins in ciliary formation and function, and in general, results have been concordant between fibroblasts and epithelial cells when both cell types were analyzed (55, 84– 84).
Depletion of the protein causes aberrations in spindle formation and function – with defects in the anaphase movement of both the large "housekeeping" chromosomes and the numerous specialised minichromosomes.
Associations with SNPs in or near genes involved in synapse formation and function (NLGN1, CBLN4, MCTP2, PDZRN4, CNTN1 and SDK1) and other neurological pathways (LINGO2, CPNE4, AUTS2) point to the importance of the brain in motion sickness.
We discuss evidence that overlapping regulatory processes could act as determinants in the formation and function of dimorphic chloroplasts in this single cell C4 system.
Collectively, in vitro and in vivo studies have suggested a role of NL2 in synapse formation and function.
