An important case corresponds to mRNA accumulating in foci.
Nevertheless, the existence of vRNP/Rab11 hotspots indicates segregation from the cytosol in foci.
The inseparable patterns were RNA localizing in cellular extensions, in foci, at the cell membrane in 3D or randomly.
Vaginal application of this model microbicide resulted in foci of disrupted epithelium detectable by confocal endomicroscopy.
More specific examples of localization include mRNAs that accumulate at the tip of cellular extensions9, localize at the cell periphery10, or DYNC1H1 mRNA that accumulates in foci representing dedicated translation factories11.
The patterns correspond to RNAs localizing to the tip of cellular extensions, around the cell membrane in 2D or 3D, with a polarized pattern, in foci, and around the nuclear envelope in 2D or 3D.
Nuclear polyadenylated (poly(A)) RNA in ZC3H3-depleted cells is sequestered in foci removed from SC35-containing speckles, indicating a shift from the normal subnuclear distribution of poly(A) RNA.
In all cases of GBM, nonquantitated HAM56-positive macrophages were identified in foci of pseudopalisading cells abutting necrosis and in foci of microvascular proliferations.
In this case, numerous HAM56-positive macrophages (labeling index, 24.5%) were present in the solid portion of tumor, and abundant nonquantified macrophages were identified in foci of pseudopalisading cells abutting necrosis and in foci of microvascular proliferations.
Furthermore, it is observed that a slight decrease in foci intensity appears on the field profile with a more random nanohole array.
It can be used for correction of 68Ga-citrate pharmacokinetics for increasing of the blood clearance, accumulation in foci and fast imaging.
