And in flies with more repeats, neurons died at a faster clip with age, Warren's team reports in the 28 August issue of Neuron.
Surprisingly, this phenotype had higher penetrance (40 to 99%) in flies with a single copy of the transgene than in flies with two copies (less than 40%).
The pattern and sarcomeric ultrastructure of muscle fibres are altered in flies with attenuated lb expression.
To test this model directly, we generated Asx mutant wing clones in flies with reduced Ubx function.
The dynamics of altered locomotor behavior accompanying stress was likewise altered in flies with altered corazonin neuronal function.
The repeated heat shock treatment had little effect on genome stability in flies with a functional Mnn1 gene (Fig. 1D).
In flies with GABABR2 knockdown in IPCs this later (5 12 h) drop in trehalose was significantly diminished (Fig. 7A).
In flies with increased MnSOD expression, the patterns of daily locomotor rhythms appeared largely intact, but were significantly altered.
We found that Aβ42-induced locomotor defects were suppressed in flies with a hypomorphic mutation of dnc (dnc[1]).
Starvin functions as a stress response and survival protein in flies with a phenotype that has similarity to two different BAG3 knockout mice [32], [33].
To begin to explore these mechanisms, we assessed the localization of markers of apical and basolateral polarity in flies with mutations in Dcas and Fak56.
