The result was verified in flanking regions of the enhancers of different length (Fig. S8).
Moreover, point mutations in exon 21 or in flanking exons are reported as pathogenic in HM patients.
Targets and distractors were presented in a 4-point font, and embedded in flanking characters intended to produce visual crowding (Bouma, 1970; Whitney & Levi, 2012) in the extrafoveal retina.
Single insertions of 5 bp at nucleotides 7998/7999, or double insertions of 5 bp at nucleotides 7998/7999 and nucleotides 8197/8198, have been reported in flanking sequences of chloroplast encoding ORF, ORF100 (Takahashi et al. 2008).
Unexpectedly, we found that SNP densities of pre-miRNAs and mature miRNAs (MmiRNAs) are significantly higher than that in flanking regions, although the SNP density of MmiRNAs is lower than that in pre-miRNAs (Figure 2a).
In addition to under-prediction, comparative algorithms are known to have trouble predicting start/stop codons in flanking regions [19].
In this paper, we found that constitutive exons have higher conservation level in exon regions and lower conservation level in flanking intron regions compared to conditional exons.
No significant repeats in flanking sequence.
The latter were found in flanking sequences of 130 cassettes.
We also found that indels in flanking regions contribute to the length variation in some loci.
FM and WK designed and validated primer pairs in flanking sequences of EST-SSRs.
