Similar to pathways enriched with genes showing a Microcystis × genotype interaction, the expression of the genes in these few pathways and gene-families was studied more in depth by means of reaction norm plots (Supporting Information Figure S10).
Metabolites involved in a number of pathways usually have many functional partners, while other metabolites only participate in a few pathways and thus have few functional-compensation partners.
Firstly, from a biological point of view, some metabolites participate in many pathways; they are referred to as common metabolites, while other metabolites only participate in a few pathways, which are referred to as pathway-specific metabolites.
However, a study focusing on genes in amino acid biosynthesis [ 4] concluded that genes with reduced diversity tend to be clustered in a few pathways and most amino acid biosynthesis genes have sufficient diversity for continued improvement through breeding.
Further, we observed in general that zones proximal to the centre appear to be more involved and specialized for key biological functions, with the proteins in those zones involved in only a few pathways.
In contrast, the sulfonylurea and phenoxy compounds are active in only a few pathways on average.
So far, the distribution of levels of selective constraint across the upstream/downstream axis of signaling pathways has been studied in only a few pathways, with contrasting results.
In addition, despite the few pathways currently implicated in PC radioresistance, none has yet been effectively targeted to elicit therapeutic radiosensitisation clinically.
So pathways enriched in a sub-network are also enriched in the global network, but only a few pathways enriched in the global network are enriched in a cluster.
In his view, the few pathways open to a young black man — dead-end jobs and smothering family relations, a fast and dangerous life of pleasure, and vulgarly materialistic middle-class ambition — are all unpalatable.
