At the secondary level, the gender difference in favour of males observed up to TIMSS 1999, at the lower and at upper tail of the distribution, has changed since the year 2000 in both the IEA and PISA surveys: at the lower tail, girls tend to perform somewhat better than males, and the male advantage at the upper tail tends to fade away across time.
Although no significant difference between the bosentan and placebo arms was observed in the primary end point of 6 minute walk test distance, a trend in favour of bosentan was observed in the secondary end point of time to death or disease progression.
However, when only methodologically robust trials were included in the analysis a smaller effect in favour of exercise was observed.
In steroid-treated patients, a nonsignificant trend for lower failure rates in favour of moxifloxacin was observed.
The treatment effect in favour of ATIII was observed even with concomitant use of heparin, which has been shown to antagonize the anti-inflammatory activities of ATIII.
A similar hazard ratio (HR) in favour of eribulin was observed in patients with triple-negative breast cancer in the initial analysis of Study 305/EMBRACE and Study 301 (HR 0.71 and 0.70, respectively) [ 10], but not in the updated analysis of Study 305/EMBRACE.
While both groups showed equally high levels of matrix metalloproteinase-9 at 24 h after infection, a significant difference in favour of glycerol was observed at 40 h after infection.
In patients with RAS WT tumours, the PFS and OS benefits observed in favour of panitumumab + FOLFOX4 versus FOLFOX4 were observed across all subpopulations predefined according to baseline covariates, with the exception of the Eastern Cooperative Oncology Group (ECOG) performance status 2 subgroup (Fig. 3).
Finally, it is worth to note that Japanese from Tokyo represent the only exception from the general trend for selection in favour of heterozygotes: expected and observed genotype counts are the same with respect to homozygotes and nearly identical regarding the heterozygotes.
The trend in favour of legal weed, they observe, is not as inexorable as the trend toward the legal recognition of same-sex marriages.Much of the support for legalisation comes from the increasingly widespread belief that the benefits of prohibition have not outweighed the costs.
