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Resistance does not necessarily result in failure to control disease.
113 In the same meta-analysis, there was no difference between terlipressin versus vasopressin, balloon tamponade or endoscopic therapy in failure to control bleeding or survival.
Loss of HSPG regulation results in failure to control Wg levels, causing differential trans-synaptic Wnt signaling to promote excess growth and overelaborated architectural complexity.
Recognized for almost a decade, mec IV strains have not yet resulted in population-based studies demonstrating a high MRSA national prevalence in any country, nor has their documented presence in Northern Europe (where surveillance cultures/contact precautions are used routinely) resulted in failure to control nosocomial MRSA infections to very low levels [ 1, 2, 4].
112 Meta-analysis of three randomised trials comparing vasopressin alone with vasopressin and nitroglycerine showed that the combination was associated with a significant reduction in failure to control bleeding (OR=0.39, 95% CI 0.22 to 0.72), although no survival benefit was shown.
68 Meta-analysis of five trials comparing sclerotherapy with vasopressin has shown a significant effect on reduction in failure to control bleeding (OR=0.51, 95% CI 0.27 to 0.97), with no effect on survival.
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This migration process must be highly controlled, since insufficient numbers of neutrophils in the infectious site results in a failure to control infection, whereas excess neutrophil accumulation may lead to tissue injury.
However, the insufficient increase in the proportion and/or the decrease in the absolute number of Tregs result in a failure to control immune activation following TI.
However following TI, even if Treg cells maintained a suppressive function, the inadequate increase in the proportion of Tregs and/or the decrease in the absolute number of Tregs resulted in a failure to control immune activation.
Whereas the overall rates of TJA increase, the rates in RA patients have been decreasing in past decades, likely because of improvements in treatments, although TJA still represents an important outcome in the failure to control progressive joint damage from RA [ 8, 16, 26].
In this regard, we hypothesise that drug resistance is a key issue in the failure to control metastatic disease.
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