Exact(1)
Although it is standard to only compare cells with a specific gene knocked down to cells expressing a scrambled RNA sequence, we also included the uninduced condition in the quantitative proteomics pipeline to ascertain whether a particular protein changed in expression solely as a consequence of FUS knockdown, or whether the process of shRNA induction influenced the expression of that protein.
Similar(59)
While XIST was initially described as being unique in its expression solely from the Xi, recent reports have found three [ XIST, LOC286467/FIRRE (48) and LOC550643 (49)] female-specific X-linked DNase Hypersensitive sites across the X chromosome.
Inhibition of NF-κB signalling in cancer cells or ablation of TGF-β1 expression solely in platelets protects against lung metastasis in vivo [ 17].
In addition, dsp-4 pretreatment increased inducible nitric oxide synthase expression solely in neurons rather than in microglial cells, more accurately replicating the expression pattern seen in AD patients [ 41].
It thus closes an information gap and has clinical significance: indeed, the current knowledge of a NT-R expression solely in primaries would not be sufficient to legitimate NT-R targeted diagnostic or therapeutic interventions, since many of ductal pancreatic patients have metastases at the time of diagnosis.
We expected to find Arc expression solely in older neurons which have reached synaptic maturity and are able to undergo long-lasting strengthening of the synapse in response to patterned activation.
Further work profiling miRNA expression solely in squamous cell carcinoma is ongoing.
Therefore, the present analysis of microdissected protoperithecia allowed the analysis of gene expression solely in these structures for the first time.
This way, we detected a 1.6-fold increase of Egfr mRNA expression solely in APLP2-/ animals, compared to wild type controls (p < 0.05).
To date, we also have not identified an enhancer-trap line that shows GFP expression solely in the o.i.1 (unpublished results).
Upon injection of landing site lines 1 and 2, the lens crystallin promoter drives reporter gene expression solely in the lens (Fig. 5E).
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