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Assessment of seasonal variations in expression of brain neuropeptide mRNA is complicated by concurrent circadian variations.
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Finally, lopinavir/ritonavir caused significant increases in expression of markers of brain inflammation and decreases in synaptic markers in WT, but not in ADTg mice.
We also showed disturbances in the expression of brain-expressed FABP genes in patients suffering from psychiatric illnesses.
More recent experimental data suggested that neuroprotective effects of dexmedetomidine against glutamate-induced cell death were mediated by an increase in astrocyte expression of brain-derived neurotrophic factor through an extracellular signal-regulated kinase-dependent pathway [50].
In addition, we analyzed expression of brain lipofuscin.
Cortisol caused changes in expression of genes in the brain and the kidneys of fetal sheep, the team found.
In general, these studies have shown there to be an increase in expression of HSP27 in AD brain tissue or in immunolabelling of pathological structures [ 12, 25- 27].
Lead nitrate treated group showed a considerable increase in expression of GFAP in the brain regions like hippocampus (P < 0.001), hypothalamus (P < 0.001), and piriform cortex (P < 0.05)).
Western blot analysis did not reveal any difference in expression of UCP2 in HtrA2-KO brain lysates compared with WT brain.
Intranasal instillation of mNPS loaded with dsDNA encoding RFP also resulted in expression of the RFP in multiple brain regions.
Over the past two decades sufficient genetic, neurobiological, and epidemiologic evidence has accumulated to indicate that learning disabilities, including DD, are in fact expressions of brain dysfunction [ 12- 18].
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