Thirty days after transgene activation, while iNs obtained from human embryonic fibroblasts (hEF-iN) expressed only the 3R tau isoform, iNs with the K298E mutation (iN-K298E) and iNs from hAF (hA-iN) expressed both 3R and 4R tau (Fig. 6a).
However, hEF-iNs still expressed only 3R tau 53 days after transduction (Fig. 6b).
A number of calcium binding proteins related to the ubiquitous protein Calmodulin are overrepresented in or expressed only in the nervous system.
Therefore significant expressional changes in genes expressed only in a small fraction of cells may be diluted by the expressional "noise" by cells of the surrounding tissue.
Double-negative cells, in contrast, expressed only minimal levels of germ cell markers.
ALKBH8 is widespread in larvae, yet expressed only in a small number of neurons in adult C. elegans.
Telomerase activity is highly regulated in lymphocytes, being expressed only in activated lymphocytes [ 5].
In humans, NEU2 is expressed only in skeletal muscles and NEU4 is ubiquitously expressed in various tissues [32], [33].
In fact, mecR1_RNA is expressed only in the absence of methicillin and it is consumed to inhibit PBP2a expression.
In humans, telomerase is expressed only in germ-line and stem cells.
9 In humans, EpCAM is expressed only in epithelium and neoplasms derived from epithelia.
