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Evacetrapib was also shown to have a modest increase in exposure when given with food in the single dose healthy subject study (data not shown).
We observed an increase of 17% for CNS cancers for each 100 Bq m−3 increase in exposure when only taking into account the exposure during the first 0 4 years of life.
To examine the difference in exposure when cycling along high- and low-traffic roads, the second bicycle route followed roads with less traffic, at some distance from the other route.
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Those healthy volunteers reported an increase in the terminal elimination t1/2 and a decrease in oral clearance with increasing doses, resulting in a nonlinear increase in drug exposure when normalized for different dose amounts.
Recent attention has focused on individualizing mycophenolate mofetil therapy via monitoring of mycophenolic acid (MPA) levels to overcome interpatient variability in MPA exposure when standard doses are administered.
As shown in Figure 3A, deletion of LdMT or LdRos3 caused a 10-fold increase in PE exposure when compared to wild type parasites based on Ro09-0198 peptide binding.
This illustrates the potential of the PBPK model to predict likelihood and magnitude of changes in sirolimus exposure when combined with a CYP3A4 inhibitor.
Additionally, the method was able to detect recent changes in vector exposure when sera from VL patients were assayed before, during, and after hospitalization and protected from sand fly bites under untreated bed nets.
The results suggest that despite hepatic arterial administration of 5FU, there was no reduction in systemic exposure when compared with that associated with intravenous injection of the same dose.
The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when ABZ was given in SD incorporated into RDTs compared with CTs.
The designed TLD accommodation device was useful for determining HVLs in a single exposure when the scatter correction factors for the device and energy dependence correction factors for TLDs were taken into consideration.
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