Sentence examples for in existing trials from inspiring English sources

Despite the current evidence, exercise is clearly underutilized due to several barriers and knowledge gaps in existing trials that include appropriate population identification, design, and outcome measures selection.

The aim of the study was to explore the perspectives of stakeholders concerning the acceptability and practicality of nesting trials of recruitment methods in existing trials.

To be useful a single-group study should have both adequate sample size and duration of drug exposure that is both longer than the exposure in existing trials (e.g. where trials range from a few weeks to several months but single-group studies report a year or more of exposure) and long enough for AEs that take time to develop to occur (e.g. cancer).

9 10 Also, meta-analysis of published aggregated data cannot provide information on which subgroups of women might be most likely to benefit from elective single embryo transfer or present data on important outcomes such as the birth of a healthy singleton baby at term, which have not been reported in existing trials.

A possible explanation for some of our findings may be the lack of adequate power in existing trials to detect effects of aspirin, either because the efficacy of aspirin was moderate to low in itself or because diabetic status was an effect modifier.

They do not mention publishing abandoned trials and ignore responsibility for correcting reporting biases persisting in existing trial publications.

22 28 Higher doses of vitamin D than were used in the existing trials may be needed to suppress bone turnover if calcium is not co-administered.

Given that it is five years since the publication of this meta-analysis, the possibility that there may now be more published trials, as well as longer duration of follow-up in the existing trials, led us to re-examine this issue.

In comparison to existing trials of exercise for knee OA, the strengths of the BEEP trial are its size, long-term follow-up, and inclusion of a cost-effectiveness analysis and longitudinal qualitative interviews with participants.

In comparison to existing trials of injection and exercise interventions for SIS, the strengths of the SUPPORT trial are its size, long-term follow-up and inclusion of an individualised, supervised and progressed exercise programme which builds upon existing guidelines [ 4] to optimise treatment outcome [ 12- 15] and inclusion of a cost-effectiveness analysis.

Deficiencies in the conduct and reporting of existing trials exemplify difficulties in the evaluation of complex interventions.