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The report reviewed and described some new assays or novel end points to be incorporated in existing assays that would expand the repertoire of endocrine signaling pathways with pathways suggested to be involved in metabolic diseases, neurodevelopmental abnormalities, etc.
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Such assay could aid the identification of individuals with functional and genetic deficiencies of Ficolin-3 and perhaps also serve as a useful diagnostic tool in collaboration with the existing assays for evaluating complement function.
We have developed and characterized a novel ELISA detecting full-length OPN from human plasma, and find a greater sensitivity to low OPN concentrations in our assay compared to the existing assays.
A sensitivity of 79.8 96.0% was demonstrated for Elecsys IgM in primary, early acute infection, consistent with existing assays.
The HIA-BC provides guidance for using existing assays to screen chemicals for their potential role in breast cancer.
In addition to developing new and more complex behavioral assays, many questions remain to be tested using the existing assays for ethanol consumption and reward.
When a new antibody is introduced in an already existing assay, the matrix effect may respond differently from the previous antibody.
My responsibility in this relationship was to transfer the existing assay into that laboratory and work closely with another postdoc there to work up a mass spec protocol.
In 14/60 (23.3%) of the cases, the new multiplex assay yielded a clonal result while the existing assay gave a non-clonal result.
Advances in miniaturization and automation may also permit characterization of the immune response more rapidly and from smaller amounts of biological material than is possible with existing assay systems.
Such a comparison is necessary if DBS are to be used as an alternative sample in existing diagnostic assays and algorithms for laboratory diagnosis of dengue in acute patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com