Chronic obstructive pulmonary disease patients in exacerbation (AECOPD) have considerable cardiovascular risk, and different cardiovascular diseases are common during exacerbations.
Finally, two multicenter RCTs were performed aiming to demonstrate a reduction in the intubation rate in exacerbation of COPD/COLD patients [18, 19].
In comparisons of HFNC and conventional oxygen therapy, this effect is thought to explain the drop in exacerbation episodes and the improved quality of life in adult patients with chronic obstructive pulmonary disease (COPD) [9].
This may result in exacerbation of its adverse effect profile.
"There's been quite a lot of evidence to indicate that hormones may have some role in exacerbation of asthma," says Melanie Pereira, professor at the University of Melbourne's allergy and lung health unit, who has studied the link between the contraceptive pill and asthma.
Oxidative inactivation of m-aconitase overexpressing cultures resulted in exacerbation of H2O2 production, Fe2+ accumulation and increased neuronal death.
Elevations in astrocytic MAO-B in our transgenics resulted in exacerbation of MPTP-induced neurotoxicity suggesting that astrocytic MAO-B increases had the expected functional effect.
Although double knockout (dKO) of Rb and Inha did not result in exacerbation of the tumorigenic phenotype of Inha-null mice, we found that the dKO mice demonstrate an acceleration of Sertoli cell dysfunction compared to Rb cKO mice.
As the depletion did not result in exacerbation of the demyelination, the results also suggest that these components of the innate immune response do not act to suppress the autoimmune response.
These results suggest that active metabolites of vitamin D could have an effect on reducing the frequency of respiratory infections, which may lead to a reduction in exacerbation of symptoms in those suffering from asthma.
Further research is recommended for estimating utility in exacerbation.
