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This suggests epistatic constraints in evolution of function in IPMS and HCS-lys enzymes.
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There is substantial evidence supporting changes of the overall chemical reaction [ 7], as well as results reporting the importance of binding different substrates in the evolution of function in superfamilies [ 8,9,10 ].
Cis transcriptional regulation is a powerful driving force in the evolution of function and form [1], [2].
Darwin emphasized the importance in evolution of such transfers of function, which, as Asher emphasizes, have enabled us to understand how many complex characteristics could evolve.
Inferring the evolutionary histories of families is an important step in understanding the evolution of function.
Therefore the ability to infer the evolutionary histories of families is an important step in understanding the evolution of function.
This laboratory has been interested in understanding the structural basis for divergent evolution of function in the enolase superfamily, with the name reflecting the most abundant member of the superfamily.
In turn, analysis of HGT in trees that describe the evolution of function directly from ontological data are congruent with our analysis and suggests a preferential role of HGT in shaping information-related functions [ 45].
Recent work has examined natural, designed, and directed evolution of function in several superfamilies of 8-barrel containing enzymes.
This observation highlights the structural diversity associated with evolution of function in the PRS.
Duplication of genic regions can also result in evolution of new genes and gene functions that can have a significant impact on phenotypes [ 9- 13].
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