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This method may become particularly helpful for the evaluation of patients with borderline renal insufficiency and/or with abnormal body composition as well as in ethnical groups other than those used for development and validation of the established estimation formulas.
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However, these findings should be replicated in families with hypercholesterolemia of other ethnicities and in particular in all ethnical groups in which the chromosome 12q24 locus was reported as linked to elevated cholesterol [ 1, 2] to confirm the general relevance of the gene in other populations as well.
The three sites are highly homogeneous in terms of ethnicity (ethnical Han Chinese >99%), rural/urban composition (∼75% rural residents) and social economic level measured by gross domestic product per capita (US$7000 to US$120000 in 2010).
The finding of our study may have an inestimable impact given the relevance of the 12q24 locus in hypercholesterolemia in several ethnical groups [ 1, 2] as well as the importance of hypercholesterolemia as a major risk factor for macrovascular disease and cerebral and cardiovascular events reducing quality of life and lifetime span [ 3].
And (3) if ethnical differences in the shape and size of the distal femur and proximal tibia exist, do they have a clinical impact on current TKA design?
Further study of SIRT3 in a larger population as well as in different ethnical groups is warranted in order to better understand prognostic and therapeutic values of SIRT3 as a biomarker in colon cancer.
More information would be valuable in order to define if ethnical, geographical and other variables modify these reference values in pregnant and nonpregnant women.
Further studies are needed in order to validate the association between other environmental determinants and AAM in different ethnical groups.
Both formulas were developed from cohorts consisting of mainly Caucasians or Blacks with uncertain accuracy in other ethnical groups [ 10– 10].
Besides, several of the variants displayed either marginally or significantly greater MAFs than those in other ethnical populations, with sizeable number exhibiting MAFs >0.49 (DMET Supplementary Data).
First, under the assumption that one SNP per gene is sufficient to perform ASE analysis, we empirically built the distributions of ASE suitable genes on a sample basis in multiple ethnical populations from the 1000 Genomes Project and the HapMap consortium data (see Additional file 1: Figure S2 and Figure S3) and observed non-uniform behavior.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com