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Based on these findings, we conclude that loss of p53 tumor suppressor function in breast cancers leads to upregulation of Toca-1, and results in enhanced risk of developing metastatic disease.
Indeed, the most important finding using linkage studies is the discovery that the alteration of TCF7L2 (TCF-4) gene expression or function (33) disrupts pancreatic islet function and results in enhanced risk of type 2 diabetes.
By surveying risk management staff from financial institutions and also regulatory experts — such as scholars and think tank employees — they found that banks primarily had invested in enhanced risk management practices because they were required to do so.
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These findings provide direct evidence for the unintended spreading of contaminants as a result of remediation efforts, which can, under some circumstances, result in enhanced risks for soil vapour intrusion.
Thus, the crosstalk between uraemia and the intestine is based on two different elements, but the consequences are the same, based on a double effect: induction of micro-inflammation going along with an incompetence of the pre-activated immune system to cope with stimuli [ 10, 18], resulting in an enhanced risk of infection which at the end in its turn again is pro-inflammatory.
Due to the mostly asymptomatic course of infection, these women will most likely not be treated resulting in an enhanced risk for the development of late complications, which include pelvic inflammatory disease (PID), ectopic pregnancy and tubal infertility.
Naloxone-induced secretion of both corticotropin and beta-endorphin was significantly diminished in persons at enhanced risk for hypertension compared with the low blood pressure control group.
In addition, an enhanced risk for acute cerebrovascular strokes has been linked to particulate air pollution (Hong et al. 2002; Tsai et al. 2003).
Regardless of the type of alcoholic beverage involved (liquors, white wine, or beer), lower alcohol doses also have been shown to induce pressure decrements in both the upper and lower esophageal sphincters, as well as a decrease in esophageal motility and an enhanced risk of gastroesophageal reflux in healthy volunteers [ 31, 32].
Part of this enhanced risk in RA is attributed to traditional cardiovascular risk factors (CRFs).
Our data confirm previous reports of enhanced risk in individuals with multiple comorbid conditions [ 13, 22, 27].
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