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Epidemics of malaria have been eliminated, but the disease still exists in endemic form, mainly in southern Egypt.
Persistence of Kala-azar in endemic form in Bihar and other affected areas and the absence of zoonotic reservoir of kala-azar infection as observed in several studies [ 14, 15] raised a possibility of existence of human reservoir in the form of PKDL or asymptomatic carriers in the community, as they harbour leishmania parasite in the skin or blood.
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It seems to have emerged in its endemic form in India 2500 3000 years ago.
BLs frequently harbor latent Epstein Barr virus (EBV) infection, with 100% EBV positivity in the endemic form, ~30% within sporadic cases and 25 40% in immunodeficiency-associated BL.
Genome scan studies which require a large number of multiplex families to reach statistical power, should also be considered in the endemic form of pemphigus foliaceus because of the high number of familial cases.
Where RVF is present in its endemic form, a range of 10-35% seroprevalence has been most frequently reported in outbreaks.
Rural areas could be characterised by a lower level of natural immunisation to the infectious agent which may occur either because children have fewer opportunities for person-to-person transmission than in more urban areas, or because the population is not large enough to maintain the disease in an endemic form (Kinlen, 1988).
Enteroviruses are the most common cause of aseptic meningitis, presenting in epidemic or endemic form.
Moreover, in South America an endemic form of PF, called Fogo selvagem, exists, which is thought to be transmitted by insect vectors (Aoki et al. 2004; Diaz et al. 1989).
This is a highly proliferative neoplasm that occurs sporadically in North America and European countries, but also has a variant associated with HIV infection and an endemic form common in Africa which is associated with Epstein Barr virus (EBV) [ 15].
This endemic form has a restricted distribution in the Sea of Japan and the Sea of Okhotsk.
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