Haplo-insufficiency of its Scc2 subunit (Nipbl) causes Cornelia de Lange syndrome in humans, an effect thought but not yet proven to be due to subtle defects in cohesin's genomic distribution.
For example, cortical cooling of the secondary somatosensory cortex can reduce the background activity in SI neurons, an effect thought to be mediated by removal of a background facilitatory influence [53].
CNP induced dose-dependent vasodilation, but ANP and BNP produced little or no vasodilation; this suggested that CNP causes significant vasodilation in cerebral arterioles, an effect thought to be mediated by a cGMP-dependent mechanism [ 17].
Perhaps the most important early contribution of genetics to conservation was the recognition of the importance of inbreeding depression, that is, inbreeding resulting in a fitness reduction, an effect thought to be due to increasing the homozygosity of detrimental alleles (Charlesworth and Charlesworth 1999; Charlesworth and Willis 2009).
This high correlation should not come as a surprise, as in clinical trials a certain basic effect, thought to be covered by the placebo control group, is compared with this same basic effect plus some specific element of pharmacologic intervention.
Even though these assays were done in a cell culture system, the results may aide in understanding the physiological effects thought to be associated with administration of these extracts to individuals.
P.S.: This has been, in effect, a thought experiment.
The periodic El Niño climate phenomenon, which is currently in effect, is thought to subdue Atlantic hurricanes, which can then spawn tornadoes.
In effect, Nash thinks they're are being asked to bear a cost that no one is even interested in accurately measuring.
"The collective approach of the show's creators could be seen as a kind of arrogance, a stance of defiance that said in effect, 'We think this is funny, and if you don't, you're wrong.'... To viewers raised on TV that was forever cajoling, importuning, and talking down to them, the blunt and gutsy approach was refreshing, a virtual reinvention of the medium".
