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In this study, we investigated the mechanisms of mucosal tolerance in EAG by examining the effects of the nasal administration of this peptide after the onset of disease.
A dose-dependent effect was observed: a dose of 300 μg had no effect, a dose of 1000 μg resulted in a moderate reduction in EAG severity, and a dose of 3000 μg produced a marked reduction in EAG severity accompanied by diminished antigen-specific, T-cell presponsesive responses.
Recent studies have identified an immunodominant peptide, pCol 24-388), from the N-terminus of rat α3(IV)NC1; this peptide contains the major B- and T-cell epitopes in EAG and can induce crescentic nephritis.
These results demonstrate that mucosal tolerance in EAG can be induced by nasal administration of an immunodominant peptide from the N-terminus of α3(IV)NC1 and should be of value in designing new therapeutic strategies for patients with Goodpasture's disease and other autoimmune disorders.
This can explain why no overall asymmetry was observed in EAG responses in bumble bees.
The L520 residue is aligned with L342 in eag channels that also gives a large voltage-dependent fluorescence signal [5].
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Highly significant differences in EAG-responses were found between compounds, concentrations, and their combinations, and between the two species.
In some cases, there are additional formatting characters, e.g. footnote indicators as in 1704_1705del eAG b in PMID 15655560, which are not properly handled by EMU.
The incidence of vomiting was 10/17 patients in the CG, 8/16 patients in the EAG and 6/14 patients in the NPG over a 48 h period after TKA.
As these samples would be subsequently used in UK10K,the EAG were interested in recommendations concerning consent and REC approvals that needed to be included in the EGF.
It has been reported that neonatal mortality rates are higher in the EAG states than elsewhere in India [26].
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