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LVH and diastolic LVD were present in high percentages in each indication group.
Review of the ICD-9 codes of the admissions in each indication validated the accuracy of this sorting process.
The Oxford Centre for Evidence Based Medicine criteria was used to classify the available evidence found for each requested drug in each indication [ 21].
The remaining treatments (n = 224; 17%) were distributed among 15 indications with the number of animals treated falling below 40 in each indication (abscess, septic arthritis, retained placenta etc).
While simple cytokines typically have a single active site that binds the same receptor or family of receptors in each indication, mAbs typically perform diverse functional activities, with multiple aspects of the same molecule interacting with diverse receptors [ 21,25,26].
Romidepsin is a potent, class 1 selective histone deacetylase (HDAC) inhibitor 1– 3 approved by the US Food and Drug Administration FDAA) for the treatment of patients with cutaneous or peripheral T-cell lymphoma (CTCL, PTCL) who received ≥1 prior systemic therapy 4. Approvals were based primarily on pivotal phase 2 studies in each indication, which demonstrated durable single-agent activity 5, 6.
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A different questionnaire was filled in for each indication, giving a maximum of three completed questionnaires per subject.
A "+" sign is indicated for each indication in each of the criteria, and an arithmetic score is calculated, by summing the "+" signs (See Additional file 3: 'Qualitative scores for 189 selected antigens').
In addition, a search looking at ongoing clinical trials for every drug use in each clinical indication was conducted in clinicaltrials.gov register [ 20].
Under such schemes, the price of a drug would be based on the value it adds in each individual indication, as demonstrated through technology appraisals [ 5].
A review of published evidence for every drug use in each clinical indication was performed searching for information on the PubMed database.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com