Several crucial components in DSB repair have recently been discovered, including factors involved in DSB formation, DSB recognition, DNA end resection, and dHJ resolution.
Hedrick and Davis are covered in DSB logos.
Similarly, RecN protein plays an important role in DSB repair in H. pylori.
As shown in this study, dRecQ4 also plays an important role in DSB repair (Figure 5).
MRE11 is a nuclease involved in DSB repair and mre11Δ strains are extremely sensitive to irradiation.
We thus determined whether the increased ROS in U87MG-EGFRvIII cells culminate in DSB accumulation [12].
These results provide additional support to our conclusion that dRecQ4 is involved in DSB repair in vivo.
dna2 mutants, however, are extremely sensitive to bleomycin and IR, consistent with an additional role in DSB repair [30] [32].
Tip60-remodeling complex has multiple functions in DSB repair.
Several nucleases have been implicated in DSB processing.
Therefore, we reasoned that Nampt is involved in DSB repair.
