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GM created the metabolic models, designed the simulation experiments, performed the simulation studies, analysed the results, drafted all figures and assisted in drafting of the manuscript.
MPTS drafted the manuscript; SBS participated in drafting of the manuscript; MJK participated in the design of the study and the statistical analyses; LHS participated in the statistical analyses; KJM conceived of the study, and participated in its design and co-ordination.
Participated in drafting of manuscript.
JM participated in drafting of the manuscript.
BFC helped in drafting of the manuscript.
SKC participated in drafting of the manuscript.
MH assisted in drafting of the manuscript.
CW participated in drafting of this paper.
JS participated in drafting of the manuscript.
AT participated in drafting of the manuscript.
BH participated in drafting of manuscript.
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