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Existing studies have considerable methodological shortcomings that resulted in downgrading of the quality of evidence from high to moderate for all cause mortality and disease specific mortality (critical outcomes) and from high to low quality evidence for diagnosis of prostate cancer (important outcome), as well as considerable inconsistency.
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The agency's review, expected to be completed next month, will probably not result in downgrades of more than one level, Mr. Foley said.
Asked if the handicappers had taken the right approach in downgrading some of the sport's greats, he replied: "I'm not a great judge of handicaps and how they work [but] I have no doubts about Frankel.
47 is expected to result in the downgrading of an estimated 40,000 felonies a year in the state.
Politically, the situation was epitomized in the downgrading of the title of king to that of paramount chief and of his function to that of "native administration".
The smaller committee has also resulted in a downgrading of the party post that controls the security apparatus, which some officials asserted had grown too powerful.
A wave of no-notice inspections this autumn resulted in the downgrading of some schools all the way from outstanding to inadequate.
If a writedown of the goodwill results in a downgrading of the company, it will have the unhappy effect of further diminishing the cash flow and therefore value of the goodwill i.e., the cycle will repeat.
Rumours of atrocities committed by Manahi's men against Italian prisoners were thought by some historians to be a factor in the downgrading of his award.
The results showed that during 19 years from 1987, a significant decrease had occurred in the extent of urban green spaces with a concomitant fragmentation resulting in downgrading and destruction of the functions and services these areas provide.
Its principal technique consists in downgrading the performance of the platform characteristics in a prescribed way.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com