FMW conceived the project, wrote the paper and carried out quantitative analysis; CMB generated the MycA mice and performed in vivo experiments; MAB examined dose responsiveness in vivo and in vitro; DLC analysed Myc dependent transcription and the effects of PAK2.
Analysis of the slopes of the AUC revealed that this was not a good parameter to use for analysis of dose responses, since these slopes were not significantly above 0, suggesting limited dose responsiveness in AHR to HDM exposure.
Compounds 19b, 19d and 19p displayed clear dose responsiveness in the lymphocyte reduction model when administered orally at doses of 0.3, 1.0, 3.0 mg/kg with reduced effect on heart rate.
There was no clear signal of dose responsiveness in one observational study that separated participants into different dose levels, 25 whereas one RCT suggested that longer term users of budesonide with greater cumulative doses had lower BMD compared to those who received lower cumulative doses.
This is in contrast to the potential receptor cross-reactivity towards closely related peptides and variable dose responsiveness seen in biological readouts.
As noted for the WT counterparts, there was limited dose responsiveness observed in these parameters.
9 Studies evaluating dose responsiveness have found a plateaued dose-response curve for PONV.
Patients who did not achieve JIA-ACR30 responses in the open-label, lead-in phase on tocilizumab were withdrawn, limiting information about dose responsiveness.
Study Objective: To determine the dose responsiveness to nitric oxide in adult cardiac surgery patients, especially in those patients with pulmonary hypertension.
In a pilot study, we evaluated the dose responsiveness of tibial cartilage and subchondral bone to MIA using a high-dose of 2 mg MIA (n = 3) and a low-dose of 0.2 mg MIA (n = 3) in rats.
